Hepatoprotective effect of the methanol extract of <i>Luffa cylindrica</i> fruit on carbon-tetrachloride induced chronic liver injury

Luffa cylindrica (Linn) commonly called sponge gourds has both medicinal and nutritional properties. It is used traditionally for the management of liver diseases. Herein, we investigated hepatoprotective effect crude methanol extract L. fruit in rats chronically exposed to carbon tetrachloride (CCl4). Male were CCl4 twice a week six weeks was administered five times weeks. Markers toxicity, antioxidant enzymes peroxidation evaluated histological analysis carried out. Significant reduction serum markers (ALT, AST ALP), increase enzyme lipid compared observed extract. CCl4-induced lesions ameliorated by These show protective on chronic injury rats.